With the continuous development and application of new technology and new technology, the types of food additives and food raw materials are constantly innovating and applying, and the requirements for their safety evaluation, use and management are becoming more and more stringent. The project studies the relevant laws and regulations of the International Codex Alimentarius Commission (CAC), the United States, the European Union, Australia and New Zealand, Canada, Japan, South Korea and other countries and regions, compares and analyzes the technical management requirements, such as definition, license examination and approval, standard system, use requirements, quality specifications, labels, inspection methods, etc., and establishes a list database of varieties allowed to be used at home and abroad. The results provide references and suggestions for the establishment and improvement of relevant standards and regulations, standardize the legal production and use of enterprises, and guide government supervision and management. On this basis, the center has completed more than 100 national standards for food safety, such as products, methods and norms related to food additives (including nutritional reinforcers).