The project is based on marine fish skin, fish bones and fish meat as raw materials, using biological enzymatic technology, degreasing and deodorization, selective hydrolysis of fish proteins into small molecule peptides, then through traditional centrifugal separation and modern ultrafiltration purification, to produce high quality high purity marine fish collagen oligopeptide products. The molecular weight of marine fish collagen oligopeptide is less than 1000Da and the oligopeptide content is more than 85.0%. All domestic equipment is used to build a production line with an annual capacity of 1500t of marine fish collagen oligopeptide. The acute toxicological evaluation of the project products shows that the marine fish collagen oligopeptide products are non-toxic. In vitro antioxidant and blood pressure lowering functional evaluation tests, as well as a number of animal and clinical functional evaluation show that marine fish collagen oligopeptide has health care functions such as enhancing immunity, antioxidant, lowering blood fat, lowering blood sugar, increasing bone density, removing yellow spots and improving skin moisture. Since the production of marine fish collagen oligopeptide, the product has been widely used in nutritional health food, beauty food, etc., with a broad market prospect.